Mathematical modelling of drug release from a porous granule

• Mathematical model of drug release from drug-excipient granules. Developed can account for radial variations in porosity and content. Model accounts internal diffusion solubility-limited extraction granule. Solubility-limited give rise to a range moving boundary value problems. A reduced-order is presented the case which initial load greatly exceeds solubility Understanding pharmaceutical granules vital development targeted profiles. describing dissolution porous spherical granule excipient considered. Radially varying concentration profiles arise are incorporated. boundary-value moving-boundary-value problems arise, depending on relationship between saturation solvent medium The derived detail where greater than all parts In this case, forms at surface propagates inwards, separating an unextracted inner core shell region undergoes via diffusion. full non-dimensionalised analysed using asymptotic methods numerical solution. leading-order by exploiting small parameter corresponding ratio maximum granule, allowing estimation time taken reach centre. behaviour considered solving it immobilisation method finite element parameters comparing model. Finally, outputs position normalised compared with experimental data literature.